concept

NRF2 PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRF2 PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

84Connections

0Hypotheses

0Analyses

44Outgoing

36Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NRF2 PATHWAY
Key Genes/Proteins	CYP46A1, NRF2
Related Diseases	ROS, CHOLESTEROL, AUTOPHAGY, FERROPTOSIS, APOPTOSIS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NRF2_PATHWAY["NRF2 PATHWAY"]
    NRF2_PATHWAY -->|"treats"| ROS["ROS"]
    NRF2_PATHWAY -->|"interacts"| CHOLESTEROL["CHOLESTEROL"]
    SQSTM1["SQSTM1"] -->|"interacts"| NRF2_PATHWAY
    Memantine["Memantine"] -->|"activates"| NRF2_PATHWAY
    Epigallocatechin_Gallate["Epigallocatechin Gallate"] -->|"targets"| NRF2_PATHWAY
    NRF2["NRF2"] -->|"treats"| NRF2_PATHWAY
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| NRF2_PATHWAY
    DIMETHYL_FUMARATE["DIMETHYL FUMARATE"] -->|"activates"| NRF2_PATHWAY

Outgoing (44)

Target	Relation	Type	Str
ROS	treats	phenotype	0.65
CHOLESTEROL	interacts_with	phenotype	0.65
AUTOPHAGY	causes	phenotype	0.65
FERROPTOSIS	protects_against	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
INFLAMMATION	inhibits	phenotype	0.65
CYP46A1	associated_with	gene	0.50
GLUTAMATE	associated_with	phenotype	0.50
SLC1A2	associated_with	gene	0.50
CELL DEATH	associated_with	phenotype	0.50
MAPK	associated_with	gene	0.50
PRAMIPEXOLE	associated_with	drug	0.45
MEMANTINE	associated_with	drug	0.45
MELATONIN	associated_with	drug	0.45
NRF2	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
ERK	associated_with	gene	0.45
CREB	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
KEAP1	associated_with	gene	0.45
PARKINSON	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
ISCHEMIA	associated_with	disease	0.45
ASTROCYTE	associated_with	cell_type	0.45
APP	associated_with	gene	0.45
HDAC3	associated_with	gene	0.45
AKT	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
CHOLESTEROL	associated_with	phenotype	0.45
HO-1	associated_with	gene	0.45
STROKE	associated_with	disease	0.45
FERROPTOSIS	associated_with	phenotype	0.45
PI3K	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
TGFB1	associated_with	gene	0.45
MITOPHAGY	associated_with	phenotype	0.45
AMPK	associated_with	gene	0.45
SUPEROXIDE	associated_with	phenotype	0.45
CORTEX	associated_with	brain_region	0.45
MICROGLIA	associated_with	cell_type	0.45
NLRP3	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
SOD1	associated_with	gene	0.45

Incoming (40)

Source	Relation	Type	Str
CYP46A1	inhibits	gene	0.70
CYP46A1	regulates	gene	0.70
NRF2	treats	gene	0.65
NRF2	targets	gene	0.65
NRF2	activates	gene	0.65
MITOCHONDRIAL DYSFUNCTION	activates	phenotype	0.65
DIMETHYL FUMARATE	activates	drug	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
ASTROCYTES	interacts_with	cell_type	0.65
ASTROCYTES	inhibits	cell_type	0.65
ASTROCYTES	regulates	cell_type	0.65
ASTROCYTE	activates	cell_type	0.65
APOPTOSIS	regulates	phenotype	0.65
SIRT1	regulates	gene	0.65
ROS	activates	phenotype	0.65
STROKE	activates	disease	0.65
STROKE	inhibits	disease	0.65
FERROPTOSIS	regulates	phenotype	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
ASTROCYTE	targets	cell_type	0.65
MELATONIN	activates	drug	0.65
ISCHEMIA	activates	disease	0.65
ISCHEMIA	regulates	disease	0.65
MULTIPLE SCLEROSIS	activates	disease	0.65
NRF2	implicated_in	gene	0.55
DIMETHYL FUMARATE	associated_with	drug	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
OLIGODENDROCYTES	associated_with	cell_type	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45
NEURODEGENERATION	associated_with	disease	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NRF2 PATHWAY

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

NRF2 Oxidative Stress Pathway

Circadian Rhythm in Neurodegeneration

oxidative-stress-comparison

Vitamin D Signaling Pathway in Neurodegeneration

Sulforaphane and Nrf2 Activation for Neuroprotection

dimethyl-fumarate-nrf2-ad-nct06850597

NACET (N-Acetylcysteine Ethyl Ester)

KARS1

Lipid Peroxidation in Neurodegeneration

Multiple Sclerosis (MS)

Genistein for Mild Cognitive Impairment (NCT07385937)

FGF10 — Fibroblast Growth Factor 10

Transcriptional Regulation in Neurodegeneration

Advanced Glycation End Products in Neurodegeneration

Blood-Brain Barrier Breakdown in Neurodegeneration